Assay Detail
Binding
CHEMBL3614737
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Inhibition of sphingomyelin synthase-1 (unknown origin) expressed in HeLa cells using C6-NBD-Cer and DMPC as substrate after 2 hrs by fluorescent HPLC-based analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (CHEMBL3611965) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.06 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613983 | — | — | 1 | 5.68 |
| CHEMBL3613975 | — | — | 1 | 5.28 |
| CHEMBL3612087 | — | — | 1 | 5.23 |
| CHEMBL3613987 | — | — | 1 | 5.18 |
| CHEMBL3613984 | — | — | 1 | 5.09 |
| CHEMBL3613995 | — | — | 1 | 5.04 |
| CHEMBL3613988 | — | — | 1 | 4.98 |
| CHEMBL3613990 | — | — | 1 | 4.85 |
| CHEMBL3613986 | — | — | 1 | 4.83 |
| CHEMBL3613985 | — | — | 1 | 4.81 |
| CHEMBL3613982 | — | — | 1 | 4.64 |
| CHEMBL3613976 | — | — | 1 | - |
| CHEMBL3613977 | — | — | 1 | - |
| CHEMBL3613978 | — | — | 1 | - |
| CHEMBL3613979 | — | — | 1 | - |
| CHEMBL3613980 | — | — | 1 | - |
| CHEMBL3613981 | — | — | 1 | - |
| CHEMBL3613989 | — | — | 1 | - |
| CHEMBL3613991 | — | — | 1 | - |
| CHEMBL3613996 | — | — | 1 | - |
| CHEMBL3613997 | — | — | 1 | - |
| CHEMBL3613992 | — | — | 1 | - |
| CHEMBL3613993 | — | — | 1 | - |
| CHEMBL3613994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613983 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3613975 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3612087 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3613987 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3613984 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3613995 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3613988 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3613990 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3613986 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL3613985 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3613982 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL3613976 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613977 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613978 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613979 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3613980 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613981 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3613989 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3613991 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613996 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613997 | — | IC50 | = | 219000.0 | nM | - |
| CHEMBL3613992 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613993 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3613994 | — | IC50 | > | 100000.0 | nM | - |