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Assay Detail

CHEMBL3615477

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LIMK2 (unknown origin) by radiometric assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

LIM domain kinase 2 (CHEMBL5932)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and biological characterization of selective LIMK inhibitors.
Boland S, Bourin A, Alen J, Geraets J, Schroeders P, Castermans K, Kindt N, Boumans N, Panitti L, Vanormelingen J, Fransen S, Van de Velde S, Defert O.
Bioorg Med Chem Lett (2015) 25 : 4005 -4010
PubMed 26233434 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.84 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3613624 1 8.85
CHEMBL3613600 1 8.82
CHEMBL3613623 1 8.80
CHEMBL3356433 LX-7101 1.0 1 8.80
CHEMBL3613606 1 8.68
CHEMBL3613607 1 8.66
CHEMBL3613621 1 8.55
CHEMBL3613620 1 8.40
CHEMBL3613608 1 8.34
CHEMBL3613601 1 8.13
CHEMBL3613605 1 8.11
CHEMBL3613622 1 8.10
CHEMBL3613614 1 8.02
CHEMBL3613602 1 7.92
CHEMBL3613610 1 7.89
CHEMBL3613611 1 6.71
CHEMBL3613612 1 6.56
CHEMBL3613618 1 6.31
CHEMBL3613613 1 5.73
CHEMBL3613616 1 5.34
CHEMBL3613615 1 -
CHEMBL3613617 1 -
CHEMBL3613619 1 -
CHEMBL3613609 1 -
CHEMBL3613598 1 -
CHEMBL3613599 1 -
CHEMBL3613603 1 -
CHEMBL3613604 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3613624 IC50 = 1.4 nM 8.85
CHEMBL3613600 IC50 = 1.5 nM 8.82
CHEMBL3613623 IC50 = 1.6 nM 8.80
CHEMBL3356433 LX-7101 IC50 = 1.6 nM 8.80
CHEMBL3613606 IC50 = 2.1 nM 8.68
CHEMBL3613607 IC50 = 2.2 nM 8.66
CHEMBL3613621 IC50 = 2.8 nM 8.55
CHEMBL3613620 IC50 = 4.0 nM 8.40
CHEMBL3613608 IC50 = 4.6 nM 8.34
CHEMBL3613601 IC50 = 7.4 nM 8.13
CHEMBL3613605 IC50 = 7.7 nM 8.11
CHEMBL3613622 IC50 = 8.0 nM 8.10
CHEMBL3613614 IC50 = 9.6 nM 8.02
CHEMBL3613602 IC50 = 12.0 nM 7.92
CHEMBL3613610 IC50 = 13.0 nM 7.89
CHEMBL3613611 IC50 = 193.0 nM 6.71
CHEMBL3613612 IC50 = 274.0 nM 6.56
CHEMBL3613618 IC50 = 494.0 nM 6.31
CHEMBL3613613 IC50 = 1860.0 nM 5.73
CHEMBL3613616 IC50 = 4560.0 nM 5.34
CHEMBL3613615 IC50 > 10000.0 nM -
CHEMBL3613617 IC50 > 10000.0 nM -
CHEMBL3613619 IC50 > 10000.0 nM -
CHEMBL3613609 IC50 < 1.0 nM -
CHEMBL3613598 IC50 < 1.0 nM -
CHEMBL3613599 IC50 < 1.0 nM -
CHEMBL3613603 IC50 < 1.0 nM -
CHEMBL3613604 IC50 < 1.0 nM -