Assay Detail
Binding
CHEMBL3615482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LIMK in human HeLa cells assessed as reduction in cofilin Ser3 phosphorylation by sandwich immunoassay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological characterization of selective LIMK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.06 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356433 | LX-7101 | 1.0 | 1 | 8.06 |
| CHEMBL3613624 | — | — | 1 | 8.05 |
| CHEMBL3613623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356433 | LX-7101 | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3613624 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3613623 | — | EC50 | - | — | - |