Assay Detail
Binding
CHEMBL3615799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from His6-MBP-TEV-full length human TNNI3K expressed in Baculovirus expression system after 60 mins by fluorescence polarization assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TNNI3K (CHEMBL5260) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.70 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613307 | — | — | 1 | 7.89 |
| CHEMBL3613186 | — | — | 1 | 7.89 |
| CHEMBL3613199 | — | — | 1 | 7.89 |
| CHEMBL3613187 | — | — | 1 | 7.89 |
| CHEMBL3613189 | — | — | 1 | 7.89 |
| CHEMBL3613185 | — | — | 1 | 7.89 |
| CHEMBL3613309 | — | — | 1 | 7.80 |
| CHEMBL3613193 | — | — | 1 | 7.70 |
| CHEMBL3613190 | — | — | 1 | 7.70 |
| CHEMBL3613184 | — | — | 1 | 7.60 |
| CHEMBL3612666 | — | — | 1 | 7.50 |
| CHEMBL3613181 | — | — | 1 | 7.50 |
| CHEMBL3612665 | — | — | 1 | 7.50 |
| CHEMBL3613306 | — | — | 1 | 7.40 |
| CHEMBL3612661 | — | — | 1 | 7.40 |
| CHEMBL3612667 | — | — | 1 | 7.40 |
| CHEMBL3613176 | — | — | 1 | 7.40 |
| CHEMBL3613196 | — | — | 1 | 7.40 |
| CHEMBL3613195 | — | — | 1 | 7.30 |
| CHEMBL3612646 | — | — | 1 | 7.30 |
| CHEMBL3613183 | — | — | 1 | 7.30 |
| CHEMBL3613179 | — | — | 1 | 7.30 |
| CHEMBL3613177 | — | — | 1 | 7.20 |
| CHEMBL3613188 | — | — | 1 | 7.20 |
| CHEMBL3612647 | — | — | 1 | 7.10 |
| CHEMBL3613178 | — | — | 1 | 7.00 |
| CHEMBL3613180 | — | — | 1 | 7.00 |
| CHEMBL3613182 | — | — | 1 | 7.00 |
| CHEMBL3613191 | — | — | 1 | 7.00 |
| CHEMBL3612663 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613307 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3613186 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3613199 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3613187 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3613189 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3613185 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3613309 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3613193 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3613190 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3613184 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3612666 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3613181 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3612665 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3613196 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3612661 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3612667 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3613306 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3613176 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3613195 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3612646 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3613183 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3613179 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3613177 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3613188 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3612647 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3613178 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3613191 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3613180 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3613182 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3612663 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3612662 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3612664 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3613308 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3612079 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3612660 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3612650 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3612641 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3612657 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3613192 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3612651 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3612642 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3612658 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3612655 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3613194 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3612654 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3612649 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3612644 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3612656 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3612659 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3612645 | — | IC50 | = | 16000.0 | nM | 4.80 |