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Assay Detail

CHEMBL3616082

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer against human MCF7 cells assessed as tumor growth inhibition after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity.
Ibrahim DA, Abou El Ella DA, El-Motwally AM, Aly RM.
Eur J Med Chem (2015) 102 : 115 -131
PubMed 26256032 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.81 5.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.93
CHEMBL3613690 1 5.67
CHEMBL3613691 1 5.46
CHEMBL3613686 1 4.86
CHEMBL3612084 1 4.55
CHEMBL3613689 1 4.47
CHEMBL3613693 1 4.38
CHEMBL3613685 1 4.29
CHEMBL3613692 1 4.29
CHEMBL3613696 1 4.21
CHEMBL3613688 1 -
CHEMBL3613687 1 -
CHEMBL3613694 1 -
CHEMBL3613695 1 -
CHEMBL3613697 1 -
CHEMBL3613698 1 -
CHEMBL3613699 1 -
CHEMBL3613700 1 -
CHEMBL3613701 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 1172.0 nM 5.93
CHEMBL3613690 IC50 = 2160.0 nM 5.67
CHEMBL3613691 IC50 = 3460.0 nM 5.46
CHEMBL3613686 IC50 = 13960.0 nM 4.86
CHEMBL3612084 IC50 = 28380.0 nM 4.55
CHEMBL3613689 IC50 = 33710.0 nM 4.47
CHEMBL3613693 IC50 = 41240.0 nM 4.38
CHEMBL3613685 IC50 = 50850.0 nM 4.29
CHEMBL3613692 IC50 = 50960.0 nM 4.29
CHEMBL3613696 IC50 = 62210.0 nM 4.21
CHEMBL3613688 IC50 = 145000.0 nM -
CHEMBL3613687 IC50 = 119600.0 nM -
CHEMBL3613694 IC50 = 277100.0 nM -
CHEMBL3613695 IC50 = 327500.0 nM -
CHEMBL3613697 IC50 = 315300.0 nM -
CHEMBL3613698 IC50 = 333800.0 nM -
CHEMBL3613699 IC50 = 385700.0 nM -
CHEMBL3613700 IC50 = 326500.0 nM -
CHEMBL3613701 IC50 = 656600.0 nM -