Assay Detail
Binding
CHEMBL3616263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human myc-tagged TNNI3K autophosphorylation overexpressed in HEKMSRII cells preincubated for 30 mins followed by pervanadate solution addition measured after 20 mins by DELFIA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEKMSRII |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TNNI3K (CHEMBL5260) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.82 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613198 | — | — | 1 | 9.15 |
| CHEMBL3613197 | — | — | 1 | 8.80 |
| CHEMBL3613305 | — | — | 1 | 8.20 |
| CHEMBL3613199 | — | — | 1 | 8.10 |
| CHEMBL3613309 | — | — | 1 | 8.00 |
| CHEMBL3613307 | — | — | 1 | 7.80 |
| CHEMBL3613306 | — | — | 1 | 7.40 |
| CHEMBL3613195 | — | — | 1 | 7.30 |
| CHEMBL3613196 | — | — | 1 | 7.00 |
| CHEMBL3613308 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613198 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3613197 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3613305 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3613199 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3613309 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3613307 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3613306 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3613195 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3613196 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3613308 | — | IC50 | = | 398.0 | nM | 6.40 |