Assay Detail
Binding
CHEMBL3616301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to canine adenosine A3 receptor expressed in HEK293 cell membranes
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.87 | 8.82 |
| IC50 | 1 | 5.07 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3612931 | — | — | 1 | 8.82 |
| CHEMBL3612932 | — | — | 1 | 8.24 |
| CHEMBL3612940 | — | — | 1 | 7.31 |
| CHEMBL3612939 | — | — | 1 | 7.12 |
| CHEMBL3407784 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3612931 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3612932 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL3612940 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL3612939 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL3407784 | — | IC50 | = | 8500.0 | nM | 5.07 |