Assay Detail
Functional
CHEMBL3618830
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.89 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.72 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.75 |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 7.91 |
| CHEMBL3617901 | — | — | 1 | 6.68 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.54 |
| CHEMBL528417 | — | — | 1 | 6.03 |
| CHEMBL3617903 | — | — | 1 | 5.54 |
| CHEMBL3617911 | — | — | 1 | 5.53 |
| CHEMBL3617917 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL361497 | ARTESUNATE | EC50 | = | 1.76 | nM | 8.75 |
| CHEMBL682 | AMODIAQUINE | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3617901 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL528417 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3617903 | — | EC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL3617911 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3617917 | — | EC50 | = | 5010.0 | nM | 5.30 |