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Assay Detail

CHEMBL3618901

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human 5HT1F receptor by radioligand binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1F (CHEMBL1805)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores.
Zhang D, Blanco MJ, Ying BP, Kohlman D, Liang SX, Victor F, Chen Q, Krushinski J, Filla SA, Hudziak KJ, Mathes BM, Cohen MP, Zacherl D, Nelson DL, Wainscott DB, Nutter SE, Gough WH, Schaus JM, Xu YC.
Bioorg Med Chem Lett (2015) 25 : 4337 -4341
PubMed 26271587 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.75 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101690 1 8.68
CHEMBL3617549 1 8.29
CHEMBL3617550 1 8.08
CHEMBL3617557 1 8.02
CHEMBL3617552 1 7.39
CHEMBL3617553 1 6.28
CHEMBL3616488 1 6.21
CHEMBL3617555 1 6.06
CHEMBL3617556 1 5.96
CHEMBL3617551 1 5.89
CHEMBL3617554 1 5.77
CHEMBL3617560 1 5.62
CHEMBL3617559 1 5.50
CHEMBL3617558 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101690 Ki = 2.1 nM 8.68
CHEMBL3617549 Ki = 5.1 nM 8.29
CHEMBL3617550 Ki = 8.3 nM 8.08
CHEMBL3617557 Ki = 9.5 nM 8.02
CHEMBL3617552 Ki = 41.0 nM 7.39
CHEMBL3617553 Ki = 530.0 nM 6.28
CHEMBL3616488 Ki = 610.0 nM 6.21
CHEMBL3617555 Ki = 870.0 nM 6.06
CHEMBL3617556 Ki = 1100.0 nM 5.96
CHEMBL3617551 Ki = 1300.0 nM 5.89
CHEMBL3617554 Ki = 1700.0 nM 5.77
CHEMBL3617560 Ki = 2400.0 nM 5.62
CHEMBL3617559 Ki = 3200.0 nM 5.50
CHEMBL3617558 Ki - -