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Assay Detail

CHEMBL3619308

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Binding
Inhibition of human recombinant serine racemase expressed in Escherichia coli Rosetta 2 (DE3) cells using L-serine as substrate by horseradish peroxidase based couple assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine racemase (CHEMBL4460)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Expanding the chemical space of human serine racemase inhibitors.
Dellafiora L, Marchetti M, Spyrakis F, Orlandi V, Campanini B, Cruciani G, Cozzini P, Mozzarelli A.
Bioorg Med Chem Lett (2015) 25 : 4297 -4303
PubMed 26283510 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.23 4.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7942 MALONIC ACID 1 4.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7942 MALONIC ACID Ki = 59000.0 nM 4.23