Assay Detail
Binding
CHEMBL3619503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at GAL4-fused human RORc expressed in HEK293 cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.25 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617309 | — | — | 1 | 5.48 |
| CHEMBL3314003 | — | — | 1 | 5.41 |
| CHEMBL3617295 | — | — | 1 | 5.18 |
| CHEMBL3617297 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617309 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3314003 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3617295 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3617297 | — | EC50 | = | 12000.0 | nM | 4.92 |