Assay Detail
Binding
CHEMBL3619623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GAL4-fused human LXRalpha expressed in HEK293 cells assessed as inhibition of T0901317-stimulated transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.44 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617309 | — | — | 1 | 5.58 |
| CHEMBL3314003 | — | — | 1 | 5.41 |
| CHEMBL3617295 | — | — | 1 | 5.39 |
| CHEMBL3617297 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617309 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3314003 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3617295 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3617297 | — | EC50 | = | 4200.0 | nM | 5.38 |