Assay Detail
Functional
CHEMBL3619936
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Antiproliferative activity against human MV4-11 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-proliferative activity of Monensin and its tertiary amide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.75 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.30 |
| CHEMBL256105 | MONENSIN | 4.0 | 1 | 7.05 |
| CHEMBL3617684 | — | — | 1 | 5.60 |
| CHEMBL3617683 | — | — | 1 | 5.49 |
| CHEMBL3617685 | — | — | 1 | 5.48 |
| CHEMBL3617680 | — | — | 1 | 5.26 |
| CHEMBL3617681 | — | — | 1 | 5.22 |
| CHEMBL3617682 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL256105 | MONENSIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3617684 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL3617683 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL3617685 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL3617680 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL3617681 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL3617682 | — | IC50 | = | 27480.0 | nM | 4.56 |