Assay Detail
Binding
CHEMBL3619957
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Inhibition of PARP1 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.97 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 9.10 |
| CHEMBL3617774 | — | — | 1 | 8.62 |
| CHEMBL3617773 | — | — | 1 | 8.46 |
| CHEMBL3617772 | — | — | 1 | 8.18 |
| CHEMBL3617778 | — | — | 1 | 7.45 |
| CHEMBL3617776 | — | — | 1 | 6.86 |
| CHEMBL3617771 | — | — | 1 | 6.60 |
| CHEMBL3617777 | — | — | 1 | 6.33 |
| CHEMBL3617768 | — | — | 1 | 5.57 |
| CHEMBL3617770 | — | — | 1 | 4.95 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | — | 1 | 4.52 |
| CHEMBL3617775 | — | — | 1 | - |
| CHEMBL3617769 | — | — | 1 | - |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 0.8044 | nM | 9.10 |
| CHEMBL3617774 | — | IC50 | = | 2.416 | nM | 8.62 |
| CHEMBL3617773 | — | IC50 | = | 3.501 | nM | 8.46 |
| CHEMBL3617772 | — | IC50 | = | 6.643 | nM | 8.18 |
| CHEMBL3617778 | — | IC50 | = | 35.44 | nM | 7.45 |
| CHEMBL3617776 | — | IC50 | = | 137.6 | nM | 6.86 |
| CHEMBL3617771 | — | IC50 | = | 249.7 | nM | 6.60 |
| CHEMBL3617777 | — | IC50 | = | 465.4 | nM | 6.33 |
| CHEMBL3617768 | — | IC50 | = | 2697.0 | nM | 5.57 |
| CHEMBL3617770 | — | IC50 | = | 11292.0 | nM | 4.95 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3617775 | — | IC50 | = | 2.952 | 10'8nM | - |
| CHEMBL3617769 | — | IC50 | = | 6.076 | 10'13nM | - |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 210000.0 | nM | - |