Assay Detail
Functional
CHEMBL3620063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-17 production in human PBMC after 48 hrs by Sandwich ELISA
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.77 | 5.85 |
| %max | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617295 | — | — | 2 | 5.85 |
| CHEMBL3314003 | — | — | 2 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617295 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3314003 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3617295 | — | %max | = | 78.0 | % | - |
| CHEMBL3314003 | — | %max | = | 63.0 | % | - |