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Assay Detail

CHEMBL3620069

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant DDO expressed in Escherichia coli BL21(DE3) using D-Asp and D-Ala assessed as 2-oxo acid production after 10 mins by colorimetric assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D-aspartate oxidase (CHEMBL5887)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.
Katane M, Yamada S, Kawaguchi G, Chinen M, Matsumura M, Ando T, Doi I, Nakayama K, Kaneko Y, Matsuda S, Saitoh Y, Miyamoto T, Sekine M, Yamaotsu N, Hirono S, Homma H.
J Med Chem (2015) 58 : 7328 -7340
PubMed 26322531 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 4.36 4.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1491941 1 4.66
CHEMBL3617316 1 4.06
CHEMBL395178 1 -
CHEMBL3617326 1 -
CHEMBL446761 1 -
CHEMBL3617322 1 -
CHEMBL3617323 1 -
CHEMBL3617324 1 -
CHEMBL3617325 1 -
CHEMBL307782 3-AMINOBENZOIC ACID 1 -
CHEMBL3322866 1 -
CHEMBL3322863 1 -
CHEMBL247336 1 -
CHEMBL229239 1 -
CHEMBL1234326 1 -
CHEMBL36767 1 -
CHEMBL1375 5-CHLOROSALICYLIC ACID 1 -
CHEMBL50725 1 -
CHEMBL3617314 1 -
CHEMBL3617315 1 -
CHEMBL3617317 1 -
CHEMBL7942 MALONIC ACID 1 -
CHEMBL541 BENZOIC ACID -1.0 1 -
CHEMBL25541 1 -
CHEMBL3617318 1 -
CHEMBL3617319 1 -
CHEMBL1383671 1 -
CHEMBL573 NIACIN 4.0 1 -
CHEMBL3322868 1 -
CHEMBL3617320 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1491941 IC50 = 21900.0 nM 4.66
CHEMBL3617316 IC50 = 87100.0 nM 4.06
CHEMBL3322863 IC50 > 100000.0 nM -
CHEMBL3322864 IC50 = 2364000.0 nM -
CHEMBL3322866 IC50 > 100000.0 nM -
CHEMBL307782 3-AMINOBENZOIC ACID IC50 > 10000000.0 nM -
CHEMBL3617325 IC50 > 10000000.0 nM -
CHEMBL3617324 IC50 > 5000000.0 nM -
CHEMBL3617323 IC50 > 10000000.0 nM -
CHEMBL3617322 IC50 > 10000000.0 nM -
CHEMBL446761 IC50 > 10000000.0 nM -
CHEMBL3617326 IC50 > 100000.0 nM -
CHEMBL395178 IC50 > 10000000.0 nM -
CHEMBL397783 5-FLUORONICOTINIC ACID IC50 > 10000000.0 nM -
CHEMBL3617321 IC50 > 10000000.0 nM -
CHEMBL247132 IC50 = 5472000.0 nM -
CHEMBL2146902 IC50 = 3351000.0 nM -
CHEMBL1529836 IC50 > 1000000.0 nM -
CHEMBL1588120 IC50 = 3541000.0 nM -
CHEMBL7942 MALONIC ACID IC50 = 879000.0 nM -
CHEMBL3617320 IC50 > 100000.0 nM -
CHEMBL3322868 IC50 > 1000000.0 nM -
CHEMBL573 NIACIN IC50 = 2778000.0 nM -
CHEMBL1383671 IC50 > 5000000.0 nM -
CHEMBL3617319 IC50 > 1000000.0 nM -
CHEMBL3617318 IC50 > 10000000.0 nM -
CHEMBL25541 IC50 > 10000000.0 nM -
CHEMBL541 BENZOIC ACID IC50 > 10000000.0 nM -
CHEMBL247336 IC50 > 10000000.0 nM -
CHEMBL3617317 IC50 > 5000000.0 nM -
CHEMBL3617315 IC50 = 4251000.0 nM -
CHEMBL3617314 IC50 > 1000000.0 nM -
CHEMBL50725 IC50 > 10000000.0 nM -
CHEMBL1375 5-CHLOROSALICYLIC ACID IC50 > 10000000.0 nM -
CHEMBL36767 IC50 > 10000000.0 nM -
CHEMBL1234326 IC50 > 10000000.0 nM -
CHEMBL229239 IC50 > 10000000.0 nM -