Assay Detail
Binding
CHEMBL3620077
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Inhibition of Keap1 (unknown origin) interaction to Nrf2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.62 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617852 | — | — | 1 | 7.54 |
| CHEMBL2381968 | — | — | 1 | 5.64 |
| CHEMBL2402207 | — | — | 1 | 5.57 |
| CHEMBL3235901 | — | — | 1 | 5.54 |
| CHEMBL3617787 | — | — | 1 | 5.27 |
| CHEMBL3134423 | — | — | 1 | 5.01 |
| CHEMBL3617788 | — | — | 1 | 4.77 |
| CHEMBL2402206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617852 | — | EC50 | = | 28.6 | nM | 7.54 |
| CHEMBL2381968 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2402207 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3235901 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3617787 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3134423 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3617788 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL2402206 | — | EC50 | = | 118000.0 | nM | - |