Assay Detail
Binding
CHEMBL3620108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human catalytic domain MMP14 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as fluorogenic substrate incubated for 4 hrs followed by substrate addition measured every 10 secs for 20 mins by fluorometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.18 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617407 | — | — | 1 | 8.41 |
| CHEMBL3617404 | — | — | 1 | 7.64 |
| CHEMBL3617405 | — | — | 1 | 7.60 |
| CHEMBL3617402 | — | — | 1 | 7.39 |
| CHEMBL3617403 | — | — | 1 | 7.09 |
| CHEMBL3617400 | — | — | 1 | 7.03 |
| CHEMBL3617401 | — | — | 1 | 7.02 |
| CHEMBL3617406 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617407 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3617404 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3617405 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3617402 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3617403 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3617400 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3617401 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3617406 | — | IC50 | = | 5500.0 | nM | 5.26 |