Assay Detail
Binding
CHEMBL3620140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at recombinant mouse alpha4beta2 nAChR expressed in HEK293 cells assessed as inhibition of acetylcholine-induced effect after 30 min by FLIPR potential blue assay
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (CHEMBL3883314) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.96 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3616574 | — | — | 2 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3616574 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3616574 | — | IC50 | = | 1096.48 | nM | 5.96 |