Assay Detail
Binding
CHEMBL3620255
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Binding affinity to Aplysia californica AChBP after 300 seconds by SPR biosensor analysis
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aplysia californica |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.70 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122270 | LOBELINE | 2.0 | 2 | 7.90 |
| CHEMBL3 | NICOTINE | 4.0 | 2 | 5.50 |
| CHEMBL3616575 | — | — | 2 | - |
| CHEMBL3616577 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122270 | LOBELINE | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL122270 | LOBELINE | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL3 | NICOTINE | Kd | = | 3160.0 | nM | 5.50 |
| CHEMBL3 | NICOTINE | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL3616575 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL3616577 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL3616575 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL3616577 | — | Kd | > | 1000.0 | nM | - |