Assay Detail
Binding
CHEMBL3620280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin
48
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 8.05 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3616718 | — | — | 1 | 10.10 |
| CHEMBL428139 | — | — | 1 | 10.00 |
| CHEMBL3616711 | — | — | 1 | 9.85 |
| CHEMBL3616742 | — | — | 1 | 9.66 |
| CHEMBL3616740 | — | — | 1 | 9.12 |
| CHEMBL3616744 | — | — | 1 | 9.06 |
| CHEMBL3616713 | — | — | 1 | 9.01 |
| CHEMBL3616712 | — | — | 1 | 8.71 |
| CHEMBL3616743 | — | — | 1 | 8.70 |
| CHEMBL3616741 | — | — | 1 | 8.47 |
| CHEMBL3616717 | — | — | 1 | 8.42 |
| CHEMBL3616771 | — | — | 1 | 8.40 |
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 8.32 |
| CHEMBL3616745 | — | — | 1 | 8.32 |
| CHEMBL3616739 | — | — | 1 | 8.30 |
| CHEMBL3616764 | — | — | 1 | 8.27 |
| CHEMBL3616754 | — | — | 1 | 8.21 |
| CHEMBL3616774 | — | — | 1 | 8.19 |
| CHEMBL3616773 | — | — | 1 | 8.17 |
| CHEMBL3616770 | — | — | 1 | 8.12 |
| CHEMBL3616762 | — | — | 1 | 8.07 |
| CHEMBL3616759 | — | — | 1 | 8.06 |
| CHEMBL3616746 | — | — | 1 | 8.05 |
| CHEMBL3616755 | — | — | 1 | 7.94 |
| CHEMBL3616753 | — | — | 1 | 7.89 |
| CHEMBL3616747 | — | — | 1 | 7.89 |
| CHEMBL3616480 | — | — | 1 | 7.84 |
| CHEMBL3616757 | — | — | 1 | 7.82 |
| CHEMBL3616758 | — | — | 1 | 7.78 |
| CHEMBL3616767 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3616718 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL428139 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3616711 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3616742 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL3616740 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL3616744 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL3616713 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL3616712 | — | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL3616743 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL3616741 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3616717 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL3616771 | — | IC50 | = | 3.99 | nM | 8.40 |
| CHEMBL3616745 | — | IC50 | = | 4.75 | nM | 8.32 |
| CHEMBL4084119 | LIRAGLUTIDE | IC50 | = | 4.78 | nM | 8.32 |
| CHEMBL3616739 | — | IC50 | = | 5.05 | nM | 8.30 |
| CHEMBL3616764 | — | IC50 | = | 5.39 | nM | 8.27 |
| CHEMBL3616754 | — | IC50 | = | 6.17 | nM | 8.21 |
| CHEMBL3616774 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3616773 | — | IC50 | = | 6.73 | nM | 8.17 |
| CHEMBL3616770 | — | IC50 | = | 7.55 | nM | 8.12 |
| CHEMBL3616762 | — | IC50 | = | 8.43 | nM | 8.07 |
| CHEMBL3616759 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3616746 | — | IC50 | = | 8.87 | nM | 8.05 |
| CHEMBL3616755 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL3616753 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL3616747 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL3616480 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL3616757 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL3616758 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL3616767 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL3616766 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL3616756 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3616748 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL3616760 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL3616769 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3616763 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL3616765 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL3616749 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2108724 | SEMAGLUTIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3616772 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL3616768 | — | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL3616761 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL3616714 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3616751 | — | IC50 | = | 79.7 | nM | 7.10 |
| CHEMBL3616750 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3616716 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3616715 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL2108724 | SEMAGLUTIDE | IC50 | = | 357.0 | nM | 6.45 |