Assay Detail
Binding
CHEMBL3620522
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Inhibition of neutrophil elastase in human whole blood using MeO-Succ-Ala-Ala-Pro-Val-pNA as substrate after 30 mins by colorimetric analysis
6
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.45 | 9.80 |
| IC50 | 2 | 7.91 | 8.15 |
| K | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542949 | — | — | 1 | 9.80 |
| CHEMBL293809 | — | — | 1 | 9.70 |
| CHEMBL3617961 | — | — | 1 | 8.15 |
| CHEMBL2368616 | — | — | 1 | 7.66 |
| CHEMBL1808549 | MIDESTEINE | 2.0 | 1 | 5.85 |
| CHEMBL1224819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542949 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL293809 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3617961 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2368616 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1808549 | MIDESTEINE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1224819 | — | K | = | 9.8 | 10'5/M/s | - |