Assay Detail
Binding
CHEMBL3620569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 9.00 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.16 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.92 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 23.0 | nM | 7.64 |