Assay Detail
Binding
CHEMBL3620648
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Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate after 60 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.96 | 10.10 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617973 | — | — | 1 | 10.10 |
| CHEMBL3617968 | BAY-678 | — | 1 | 7.82 |
| CHEMBL3617972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617973 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL3617968 | BAY-678 | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3617972 | — | IC50 | < | 0.3 | nM | - |