Assay Detail
Binding
CHEMBL3620669
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Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.11 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215387 | — | — | 1 | 7.96 |
| CHEMBL3617999 | — | — | 1 | 5.39 |
| CHEMBL3617998 | — | — | 1 | 4.90 |
| CHEMBL3617997 | — | — | 1 | 4.86 |
| CHEMBL3617995 | — | — | 1 | 4.81 |
| CHEMBL3617996 | — | — | 1 | 4.70 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 4.57 |
| CHEMBL497001 | ALOIN | -1.0 | 1 | 4.43 |
| CHEMBL3617994 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215387 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL3617999 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3617998 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3617997 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3617995 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3617996 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL497001 | ALOIN | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL3617994 | — | IC50 | = | 41100.0 | nM | 4.39 |