Assay Detail
Binding
CHEMBL3620670
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Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.06 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617997 | — | — | 1 | 6.10 |
| CHEMBL3617999 | — | — | 1 | 4.81 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617997 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3617999 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL40275 | ALOE-EMODIN | Ki | = | 52200.0 | nM | 4.28 |