Assay Detail
Binding
CHEMBL3620671
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Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.24 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617995 | — | — | 1 | 6.70 |
| CHEMBL3617996 | — | — | 1 | 5.70 |
| CHEMBL3617998 | — | — | 1 | 4.98 |
| CHEMBL3617994 | — | — | 1 | 4.56 |
| CHEMBL497001 | ALOIN | -1.0 | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617995 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3617996 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3617998 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL3617994 | — | Ki | = | 27800.0 | nM | 4.56 |
| CHEMBL497001 | ALOIN | Ki | = | 57300.0 | nM | 4.24 |