Assay Detail
Binding
CHEMBL3620703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac) fluorogenic acetylated peptide substrate by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.14 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.51 |
| CHEMBL3260857 | — | — | 1 | 6.01 |
| CHEMBL3260858 | — | — | 1 | 5.92 |
| CHEMBL3617543 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3260857 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3260858 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3617543 | — | IC50 | = | 3300.0 | nM | 5.48 |