Assay Detail
Functional
CHEMBL3620946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytoprotective activity in rat INS-1E cells assessed as suppression of recombinant rat IL-1beta/recombinant mouse IFN-gamma and TNF-alpha-induced caspase-3 expression after 48 hrs by Caspase-Glo 3/7 assay
17
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | INS-1E |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Benzimidazole derivatives protect against cytokine-induced apoptosis in pancreatic β-Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| %max | 7 | - | - |
| IC50 | 7 | 4.90 | 5.05 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617481 | — | — | 3 | 5.05 |
| CHEMBL3617482 | — | — | 3 | 5.02 |
| CHEMBL3617483 | — | — | 2 | 4.79 |
| CHEMBL3617487 | — | — | 3 | 4.73 |
| CHEMBL3617484 | — | — | 2 | - |
| CHEMBL3617485 | — | — | 2 | - |
| CHEMBL3617486 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617481 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL3617482 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL3617483 | — | IC50 | = | 16380.0 | nM | 4.79 |
| CHEMBL3617487 | — | IC50 | = | 18470.0 | nM | 4.73 |
| CHEMBL3617482 | — | %max | = | 82.0 | % | - |
| CHEMBL3617483 | — | %max | = | 75.0 | % | - |
| CHEMBL3617484 | — | %max | = | 22.0 | % | - |
| CHEMBL3617485 | — | %max | = | 15.0 | % | - |
| CHEMBL3617486 | — | %max | = | 12.0 | % | - |
| CHEMBL3617487 | — | %max | = | 68.0 | % | - |
| CHEMBL3617484 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3617485 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3617486 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3617487 | — | Activity | - | — | - | |
| CHEMBL3617482 | — | Activity | - | — | - | |
| CHEMBL3617481 | — | %max | = | 84.0 | % | - |
| CHEMBL3617481 | — | Activity | - | — | - |