Assay Detail
Binding
CHEMBL3624714
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Inhibition of KDM6B (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.95 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188597 | — | — | 1 | 7.20 |
| CHEMBL1230640 | — | — | 1 | 7.00 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 6.50 |
| CHEMBL1982368 | — | — | 1 | 6.10 |
| CHEMBL316034 | — | — | 1 | 4.50 |
| CHEMBL3621850 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188597 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1230640 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1982368 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL316034 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL3621850 | — | IC50 | = | 39810.72 | nM | 4.40 |