Assay Detail
Functional
CHEMBL3624762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.21 | 10.40 |
| pIC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623004 | AZD-9496 | 1.0 | 1 | 10.40 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 10.00 |
| CHEMBL3623002 | — | — | 1 | 9.64 |
| CHEMBL3623003 | — | — | 1 | 9.49 |
| CHEMBL2137046 | — | — | 1 | 9.27 |
| CHEMBL3623001 | — | — | 1 | 9.11 |
| CHEMBL3622999 | — | — | 1 | 7.65 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 7.24 |
| CHEMBL33899 | — | — | 1 | 6.53 |
| CHEMBL3622998 | — | — | 1 | 6.09 |
| CHEMBL3622994 | — | — | 1 | 4.86 |
| CHEMBL3622996 | — | — | 1 | - |
| CHEMBL3622995 | — | — | 1 | - |
| CHEMBL3622993 | — | — | 1 | - |
| CHEMBL3622992 | — | — | 1 | - |
| CHEMBL195515 | — | — | 1 | - |
| CHEMBL3622997 | — | — | 1 | - |
| CHEMBL3623000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623004 | AZD-9496 | IC50 | = | 0.03981 | nM | 10.40 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3623002 | — | IC50 | = | 0.2291 | nM | 9.64 |
| CHEMBL3623003 | — | IC50 | = | 0.3236 | nM | 9.49 |
| CHEMBL2137046 | — | IC50 | = | 0.537 | nM | 9.27 |
| CHEMBL3623001 | — | IC50 | = | 0.7762 | nM | 9.11 |
| CHEMBL3622999 | — | IC50 | = | 22.39 | nM | 7.65 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL33899 | — | IC50 | = | 295.12 | nM | 6.53 |
| CHEMBL3622998 | — | IC50 | = | 812.83 | nM | 6.09 |
| CHEMBL3622994 | — | IC50 | = | 13803.84 | nM | 4.86 |
| CHEMBL3622996 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL3622995 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL3622993 | — | pIC50 | - | — | - | |
| CHEMBL3622992 | — | pIC50 | - | — | - | |
| CHEMBL195515 | — | pIC50 | - | — | - | |
| CHEMBL3622997 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL3623000 | — | pIC50 | - | — | - |