Assay Detail
Functional
CHEMBL3624926
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Anti-angiogenesis activity in HUVEC assessed as inhibition of cell migration
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.94 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623138 | — | — | 1 | 10.24 |
| CHEMBL3623137 | — | — | 1 | 10.10 |
| CHEMBL3623135 | — | — | 1 | 10.00 |
| CHEMBL3623139 | — | — | 1 | 9.71 |
| CHEMBL3623136 | — | — | 1 | 9.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623138 | — | IC50 | = | 0.057 | nM | 10.24 |
| CHEMBL3623137 | — | IC50 | = | 0.079 | nM | 10.10 |
| CHEMBL3623135 | — | IC50 | = | 0.099 | nM | 10.00 |
| CHEMBL3623139 | — | IC50 | = | 0.196 | nM | 9.71 |
| CHEMBL3623136 | — | IC50 | = | 0.215 | nM | 9.67 |