Assay Detail
Binding
CHEMBL3625240
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Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.82 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415788 | — | — | 1 | 8.85 |
| CHEMBL3622802 | — | — | 1 | 8.82 |
| CHEMBL3622803 | — | — | 1 | 7.96 |
| CHEMBL3622801 | — | — | 1 | 6.77 |
| CHEMBL3622805 | — | — | 1 | 6.69 |
| CHEMBL3622804 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415788 | — | EC50 | = | 1.42 | nM | 8.85 |
| CHEMBL3622802 | — | EC50 | = | 1.51 | nM | 8.82 |
| CHEMBL3622803 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3622801 | — | EC50 | = | 169.4 | nM | 6.77 |
| CHEMBL3622805 | — | EC50 | = | 203.7 | nM | 6.69 |
| CHEMBL3622804 | — | EC50 | > | 10000.0 | nM | - |