Assay Detail
Binding
CHEMBL3625550
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Inhibition of TNFalpha-induced NF-kappaB activity (unknown origin) transfected in HEK293 cells after 6 hrs by luciferase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.51 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1797232 | — | — | 1 | 6.05 |
| CHEMBL1797233 | CHAETOMUGILIN I | — | 1 | 6.05 |
| CHEMBL403183 | — | — | 1 | 5.70 |
| CHEMBL60718 | TPCK | — | 1 | 5.42 |
| CHEMBL3621758 | — | — | 1 | 5.29 |
| CHEMBL3621756 | — | — | 1 | 5.12 |
| CHEMBL3621757 | — | — | 1 | 4.94 |
| CHEMBL3621754 | — | — | 1 | - |
| CHEMBL494745 | CHAETOMUGILIN D | — | 1 | - |
| CHEMBL3621755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1797232 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1797233 | CHAETOMUGILIN I | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL403183 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL60718 | TPCK | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3621758 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3621756 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3621757 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3621754 | — | IC50 | - | — | - | |
| CHEMBL494745 | CHAETOMUGILIN D | IC50 | - | — | - | |
| CHEMBL3621755 | — | IC50 | - | — | - |