Assay Detail
Functional
CHEMBL3625637
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Antiplasmodial activity against Plasmodium berghei ANKA early trophozoite stage by parasite LDH assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.92 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.52 |
| CHEMBL3623713 | — | — | 1 | 7.85 |
| CHEMBL3623714 | — | — | 1 | 7.82 |
| CHEMBL3623711 | — | — | 1 | 7.80 |
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 7.80 |
| CHEMBL3623712 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566534 | ARTEMETHER | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3623713 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3623714 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3623711 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL207675 | SODIUM ARESUNATE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3623712 | — | IC50 | = | 18.0 | nM | 7.75 |