Assay Detail
Binding
CHEMBL3625720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.60 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622803 | — | — | 1 | 9.47 |
| CHEMBL3622802 | — | — | 1 | 8.83 |
| CHEMBL415788 | — | — | 1 | 8.73 |
| CHEMBL3622805 | — | — | 1 | 8.38 |
| CHEMBL3622801 | — | — | 1 | 7.58 |
| CHEMBL3622804 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622803 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL3622802 | — | EC50 | = | 1.49 | nM | 8.83 |
| CHEMBL415788 | — | EC50 | = | 1.85 | nM | 8.73 |
| CHEMBL3622805 | — | EC50 | = | 4.19 | nM | 8.38 |
| CHEMBL3622801 | — | EC50 | = | 26.6 | nM | 7.58 |
| CHEMBL3622804 | — | EC50 | > | 1000.0 | nM | - |