Assay Detail
Binding
CHEMBL3625897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1 (unknown origin) using 87 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.70 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21156 | — | — | 1 | 8.40 |
| CHEMBL3622826 | — | — | 1 | 7.30 |
| CHEMBL3622824 | — | — | 1 | 7.00 |
| CHEMBL3622834 | — | — | 1 | 7.00 |
| CHEMBL3622825 | — | — | 1 | 5.66 |
| CHEMBL3622830 | — | — | 1 | 5.54 |
| CHEMBL3622832 | — | — | 1 | 5.51 |
| CHEMBL3622835 | — | — | 1 | 5.51 |
| CHEMBL3622838 | — | — | 1 | 5.47 |
| CHEMBL3622831 | — | — | 1 | 5.43 |
| CHEMBL3622827 | — | — | 1 | 5.37 |
| CHEMBL3622822 | — | — | 1 | 5.21 |
| CHEMBL3622837 | — | — | 1 | 5.09 |
| CHEMBL3622833 | — | — | 1 | 5.03 |
| CHEMBL3622823 | — | — | 1 | 4.95 |
| CHEMBL3622828 | — | — | 1 | 4.94 |
| CHEMBL3622829 | — | — | 1 | 4.74 |
| CHEMBL3622836 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21156 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3622826 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3622824 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3622834 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3622825 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3622830 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3622832 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3622835 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3622838 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3622831 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3622827 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3622822 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3622837 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3622833 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3622823 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3622828 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3622829 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL3622836 | — | IC50 | = | 32400.0 | nM | 4.49 |