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Assay Detail

CHEMBL3626029

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Tubulin (CHEMBL2111464)
Type PROTEIN COMPLEX
Organism Bos taurus

Publication

Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity.
Carta D, Bortolozzi R, Hamel E, Basso G, Moro S, Viola G, Ferlin MG.
J Med Chem (2015) 58 : 7991 -8010
PubMed 26418966 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.72 6.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3623606 1 6.13
CHEMBL3623611 1 6.12
CHEMBL3623600 1 6.00
CHEMBL3623601 1 6.00
CHEMBL3623607 1 5.92
CHEMBL67 COMBRETASTATIN A4 -1.0 1 5.92
CHEMBL3623597 1 5.89
CHEMBL3621230 1 5.75
CHEMBL3623602 1 5.58
CHEMBL3623598 1 5.54
CHEMBL3623603 1 5.24
CHEMBL3623596 1 5.18
CHEMBL3623608 1 5.10
CHEMBL3623599 1 -
CHEMBL3623609 1 -
CHEMBL3623610 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3623606 IC50 = 740.0 nM 6.13
CHEMBL3623611 IC50 = 750.0 nM 6.12
CHEMBL3623600 IC50 = 990.0 nM 6.00
CHEMBL3623601 IC50 = 990.0 nM 6.00
CHEMBL3623607 IC50 = 1200.0 nM 5.92
CHEMBL67 COMBRETASTATIN A4 IC50 = 1200.0 nM 5.92
CHEMBL3623597 IC50 = 1300.0 nM 5.89
CHEMBL3621230 IC50 = 1800.0 nM 5.75
CHEMBL3623602 IC50 = 2600.0 nM 5.58
CHEMBL3623598 IC50 = 2900.0 nM 5.54
CHEMBL3623603 IC50 = 5700.0 nM 5.24
CHEMBL3623596 IC50 = 6600.0 nM 5.18
CHEMBL3623608 IC50 = 8000.0 nM 5.10
CHEMBL3623599 IC50 > 20000.0 nM -
CHEMBL3623609 IC50 > 20000.0 nM -
CHEMBL3623610 IC50 > 20000.0 nM -