Assay Detail
Binding
CHEMBL3626448
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Inhibition of recombinant Anopheles gambiae wild type AChE after 60 mins by Ellman assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Anopheles gambiae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.13 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623551 | — | — | 1 | 9.17 |
| CHEMBL3623558 | — | — | 1 | 8.91 |
| CHEMBL3623552 | — | — | 1 | 8.81 |
| CHEMBL3623550 | — | — | 1 | 8.69 |
| CHEMBL3623549 | — | — | 1 | 8.64 |
| CHEMBL3623554 | — | — | 1 | 8.01 |
| CHEMBL89354 | — | — | 1 | 7.74 |
| CHEMBL3623556 | — | — | 1 | 7.60 |
| CHEMBL3623557 | — | — | 1 | 7.54 |
| CHEMBL446060 | PROPOXUR | -1.0 | 1 | 7.36 |
| CHEMBL167911 | DICHLORVOS | 2.0 | 1 | 7.22 |
| CHEMBL3623559 | — | — | 1 | 6.87 |
| CHEMBL3137700 | — | — | 1 | 6.59 |
| CHEMBL3623548 | — | — | 1 | 6.54 |
| CHEMBL3623565 | — | — | 1 | 6.47 |
| CHEMBL3623555 | — | — | 1 | 6.37 |
| CHEMBL3623561 | — | — | 1 | 6.02 |
| CHEMBL3623553 | — | — | 1 | 5.98 |
| CHEMBL3623566 | — | — | 1 | 5.81 |
| CHEMBL3623563 | — | — | 1 | 5.54 |
| CHEMBL3623564 | — | — | 1 | 5.48 |
| CHEMBL3623560 | — | — | 1 | 5.40 |
| CHEMBL3623562 | — | — | 1 | - |
| CHEMBL3623567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623551 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL3623558 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL3623552 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL3623550 | — | IC50 | = | 2.06 | nM | 8.69 |
| CHEMBL3623549 | — | IC50 | = | 2.29 | nM | 8.64 |
| CHEMBL3623554 | — | IC50 | = | 9.79 | nM | 8.01 |
| CHEMBL89354 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL3623556 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL3623557 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL446060 | PROPOXUR | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL167911 | DICHLORVOS | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL3623559 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL3137700 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL3623548 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL3623565 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL3623555 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3623561 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL3623553 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3623566 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3623563 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL3623564 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3623560 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL3623562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623567 | — | IC50 | > | 10000.0 | nM | - |