Assay Detail
Binding
CHEMBL3626449
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Inhibition of recombinant Anopheles gambiae AChE G119S mutant after 60 mins by Ellman assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Anopheles gambiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.78 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623558 | — | — | 1 | 6.90 |
| CHEMBL3623556 | — | — | 1 | 6.73 |
| CHEMBL3623557 | — | — | 1 | 6.53 |
| CHEMBL167911 | DICHLORVOS | 2.0 | 1 | 6.52 |
| CHEMBL3623554 | — | — | 1 | 6.00 |
| CHEMBL3623551 | — | — | 1 | 5.76 |
| CHEMBL3623550 | — | — | 1 | 5.70 |
| CHEMBL3623549 | — | — | 1 | 5.63 |
| CHEMBL3623565 | — | — | 1 | 5.52 |
| CHEMBL3623559 | — | — | 1 | 5.47 |
| CHEMBL3623552 | — | — | 1 | 5.45 |
| CHEMBL3623555 | — | — | 1 | 5.08 |
| CHEMBL3137700 | — | — | 1 | 5.00 |
| CHEMBL89354 | — | — | 1 | 4.68 |
| CHEMBL3623567 | — | — | 1 | - |
| CHEMBL3623548 | — | — | 1 | - |
| CHEMBL3623566 | — | — | 1 | - |
| CHEMBL3623564 | — | — | 1 | - |
| CHEMBL3623563 | — | — | 1 | - |
| CHEMBL3623562 | — | — | 1 | - |
| CHEMBL3623561 | — | — | 1 | - |
| CHEMBL3623560 | — | — | 1 | - |
| CHEMBL446060 | PROPOXUR | -1.0 | 1 | - |
| CHEMBL3623553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623558 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3623556 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3623557 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL167911 | DICHLORVOS | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3623554 | — | IC50 | = | 996.0 | nM | 6.00 |
| CHEMBL3623551 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL3623550 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3623549 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL3623565 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3623559 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL3623552 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL3623555 | — | IC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL3137700 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL89354 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL3623567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623566 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623564 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623561 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623560 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL446060 | PROPOXUR | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623553 | — | IC50 | > | 10000.0 | nM | - |