Assay Detail
Binding
CHEMBL3626537
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Binding affinity to human histamine H4 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.74 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915540 | ADRIFORANT | 2.0 | 1 | 8.62 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.35 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 8.32 |
| CHEMBL1915532 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915540 | ADRIFORANT | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL129198 | JNJ-7777120 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL90 | HISTAMINE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL1915532 | — | Ki | = | 2110.0 | nM | 5.68 |