Assay Detail
Binding
CHEMBL3626702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR1 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.86 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 7.37 |
| CHEMBL393636 | — | — | 1 | 6.94 |
| CHEMBL3621296 | — | — | 1 | 6.69 |
| CHEMBL3621294 | — | — | 1 | 6.44 |
| CHEMBL3621300 | — | — | 1 | - |
| CHEMBL3621299 | — | — | 1 | - |
| CHEMBL3621298 | — | — | 1 | - |
| CHEMBL3621297 | — | — | 1 | - |
| CHEMBL3621295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL393636 | — | IC50 | = | 115.5 | nM | 6.94 |
| CHEMBL3621296 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3621294 | — | IC50 | = | 364.5 | nM | 6.44 |
| CHEMBL3621300 | — | IC50 | - | — | - | |
| CHEMBL3621299 | — | IC50 | - | — | - | |
| CHEMBL3621298 | — | IC50 | - | — | - | |
| CHEMBL3621297 | — | IC50 | - | — | - | |
| CHEMBL3621295 | — | IC50 | - | — | - |