Assay Detail
Binding
CHEMBL3626709
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Inhibition of HDAC2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.01 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621294 | — | — | 1 | 8.96 |
| CHEMBL3621296 | — | — | 1 | 7.69 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.25 |
| CHEMBL3621298 | — | — | 1 | 5.65 |
| CHEMBL3621297 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621294 | — | IC50 | = | 1.11 | nM | 8.96 |
| CHEMBL3621296 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3621298 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL3621297 | — | IC50 | = | 3290.0 | nM | 5.48 |