Assay Detail
Binding
CHEMBL3630397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human recombinant ST6Gal-1 using CMP-Neu5Ac and p-nitrophenyl LacNAc as donar and acceptor by Lineweaver-Burk double reciprocal plot analysis
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-galactoside alpha-2,6-sialyltransferase 1 (CHEMBL3596075) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.25 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3629697 | — | — | 1 | 7.72 |
| CHEMBL3629696 | — | — | 2 | 7.55 |
| CHEMBL3629692 | — | — | 2 | 6.36 |
| CHEMBL3629694 | — | — | 1 | 6.06 |
| CHEMBL3629693 | — | — | 1 | 5.82 |
| CHEMBL3629691 | — | — | 1 | 5.37 |
| CHEMBL3629689 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3629697 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3629696 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3629692 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL3629696 | — | Ki | = | 477.0 | nM | 6.32 |
| CHEMBL3629694 | — | Ki | = | 865.0 | nM | 6.06 |
| CHEMBL3629693 | — | Ki | = | 1510.0 | nM | 5.82 |
| CHEMBL3629692 | — | Ki | = | 1629.0 | nM | 5.79 |
| CHEMBL3629691 | — | Ki | = | 4314.0 | nM | 5.37 |
| CHEMBL3629689 | — | Ki | = | 5852.0 | nM | 5.23 |