Assay Detail
Binding
CHEMBL3630804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 (unknown origin)
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.27 | 7.14 |
| Ki | 2 | 4.68 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL457063 | — | — | 1 | 5.32 |
| CHEMBL509549 | — | — | 1 | 5.28 |
| CHEMBL446387 | — | — | 1 | 5.12 |
| CHEMBL457610 | — | — | 1 | 5.11 |
| CHEMBL195008 | NECROSTATIN | — | 1 | 4.94 |
| CHEMBL457326 | — | — | 1 | 4.60 |
| CHEMBL513172 | 1-METHYLTRYPTOPHAN | — | 1 | 4.42 |
| CHEMBL14145 | — | — | 1 | 4.32 |
| CHEMBL444214 | — | — | 1 | - |
| CHEMBL503942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL457063 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL509549 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL446387 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL457610 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL195008 | NECROSTATIN | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL457326 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL513172 | 1-METHYLTRYPTOPHAN | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL14145 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL444214 | — | IC50 | = | 365000.0 | nM | - |
| CHEMBL503942 | — | IC50 | = | 1200000.0 | nM | - |