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Assay Detail

CHEMBL3631086

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human IDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.
Wu JS, Lin SY, Liao FY, Hsiao WC, Lee LC, Peng YH, Hsieh CL, Wu MH, Song JS, Yueh A, Chen CH, Yeh SH, Liu CY, Lin SY, Yeh TK, Hsu JT, Shih C, Ueng SH, Hung MS, Wu SY.
J Med Chem (2015) 58 : 7807 -7819
PubMed 26348881 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.87 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3628597 1 6.22
CHEMBL3628599 1 6.19
CHEMBL3628551 1 6.12
CHEMBL1442185 1 6.09
CHEMBL3628604 1 6.04
CHEMBL3628598 1 6.03
CHEMBL3628595 1 6.01
CHEMBL3628601 1 6.01
CHEMBL3628600 1 5.96
CHEMBL3628593 1 5.91
CHEMBL3628603 1 5.80
CHEMBL3628553 1 5.75
CHEMBL3628596 1 5.71
CHEMBL3628602 1 5.68
CHEMBL3628594 1 5.63
CHEMBL3628552 1 5.59
CHEMBL3628554 1 5.50
CHEMBL1537588 1 5.34
CHEMBL3628555 1 -
CHEMBL3628556 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3628597 IC50 = 602.0 nM 6.22
CHEMBL3628599 IC50 = 640.0 nM 6.19
CHEMBL3628551 IC50 = 767.0 nM 6.12
CHEMBL1442185 IC50 = 808.9 nM 6.09
CHEMBL3628604 IC50 = 921.8 nM 6.04
CHEMBL3628598 IC50 = 936.0 nM 6.03
CHEMBL3628595 IC50 = 977.0 nM 6.01
CHEMBL3628601 IC50 = 982.0 nM 6.01
CHEMBL3628600 IC50 = 1097.0 nM 5.96
CHEMBL3628593 IC50 = 1242.0 nM 5.91
CHEMBL3628603 IC50 = 1593.0 nM 5.80
CHEMBL3628553 IC50 = 1770.0 nM 5.75
CHEMBL3628596 IC50 = 1928.0 nM 5.71
CHEMBL3628602 IC50 = 2069.0 nM 5.68
CHEMBL3628594 IC50 = 2323.0 nM 5.63
CHEMBL3628552 IC50 = 2587.0 nM 5.59
CHEMBL3628554 IC50 = 3163.0 nM 5.50
CHEMBL1537588 IC50 = 4612.0 nM 5.34
CHEMBL3628555 IC50 > 10000.0 nM -
CHEMBL3628556 IC50 > 10000.0 nM -