Assay Detail
Binding
CHEMBL3631192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.21 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518243 | LITHOSPERMIC ACID | — | 1 | 8.32 |
| CHEMBL233930 | ASTRAGALIN | — | 1 | 8.31 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 7.51 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 7.49 |
| CHEMBL117 | CHRYSIN | — | 1 | 7.46 |
| CHEMBL457077 | SALVIANOLIC ACID A | 1.0 | 1 | 7.40 |
| CHEMBL309490 | GALANGIN | — | 1 | 7.38 |
| CHEMBL2262641 | QUERCETIN-3-O-RHAMNOSIDE | — | 1 | 7.36 |
| CHEMBL9352 | NARINGENIN | — | 1 | 7.35 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 7.28 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 7.28 |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | 7.26 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 7.25 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 7.22 |
| CHEMBL266564 | TILIROSIDE | — | 1 | 6.87 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 6.84 |
| CHEMBL3628130 | — | — | 1 | 6.40 |
| CHEMBL3628129 | — | — | 1 | 6.39 |
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | 6.34 |
| CHEMBL541265 | SALVIANOLIC ACID B | — | 1 | 6.34 |
| CHEMBL486386 | PUERARIN | 2.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518243 | LITHOSPERMIC ACID | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL233930 | ASTRAGALIN | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL8996 | ERIODICTYOL | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL66 | (+)-TAXIFOLIN | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL117 | CHRYSIN | Ki | = | 34.7 | nM | 7.46 |
| CHEMBL457077 | SALVIANOLIC ACID A | Ki | = | 39.8 | nM | 7.40 |
| CHEMBL309490 | GALANGIN | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL2262641 | QUERCETIN-3-O-RHAMNOSIDE | Ki | = | 43.5 | nM | 7.36 |
| CHEMBL9352 | NARINGENIN | Ki | = | 44.3 | nM | 7.35 |
| CHEMBL250450 | ISOQUERCETIN | Ki | = | 52.1 | nM | 7.28 |
| CHEMBL131921 | BIOCHANIN | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL379064 | ISORHAMNETIN | Ki | = | 54.9 | nM | 7.26 |
| CHEMBL8145 | DAIDZEIN | Ki | = | 56.4 | nM | 7.25 |
| CHEMBL151 | LUTEOLIN | Ki | = | 60.3 | nM | 7.22 |
| CHEMBL266564 | TILIROSIDE | Ki | = | 134.3 | nM | 6.87 |
| CHEMBL150 | KAEMPFEROL | Ki | = | 145.9 | nM | 6.84 |
| CHEMBL3628130 | — | Ki | = | 399.7 | nM | 6.40 |
| CHEMBL3628129 | — | Ki | = | 408.9 | nM | 6.39 |
| CHEMBL399121 | HESPERETIN | Ki | = | 454.1 | nM | 6.34 |
| CHEMBL541265 | SALVIANOLIC ACID B | Ki | = | 453.6 | nM | 6.34 |
| CHEMBL486386 | PUERARIN | Ki | = | 515.0 | nM | 6.29 |