Assay Detail

CHEMBL3631196

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Binding

Inhibition of human recombinant carbonic anhydrase 12

ChEMBL ↗

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Target

Carbonic anhydrase 12 (CHEMBL3242) ↗

Open DB target context

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Carbonic anhydrase 12 (CHEMBL3242) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Carbonic anhydrase 12

CHEMBL3242

Anchored from Assay target.

Protein identity Carbonic anhydrase 12

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Carbonic anhydrase 12 (CHEMBL3242) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

New natural product carbonic anhydrase inhibitors incorporating phenol moieties.

Karioti A, Ceruso M, Carta F, Bilia AR, Supuran CT.
Bioorg Med Chem (2015) 23 : 7219 -7225
PubMed 26498393 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	6.72	6.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL250450	ISOQUERCETIN	2.0	1	6.77
CHEMBL379064	ISORHAMNETIN	—	1	6.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL250450	ISOQUERCETIN	Ki	=	170.0	nM	6.77
CHEMBL379064	ISORHAMNETIN	Ki	=	220.0	nM	6.66