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Assay Detail

CHEMBL3631208

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by stopped-flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 14 (CHEMBL3510)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.
Maresca A, Akyuz G, Osman SM, AlOthman Z, Supuran CT.
Bioorg Med Chem (2015) 23 : 7181 -7188
PubMed 26498394 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.92 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3628212 1 6.51
CHEMBL3628211 1 6.43
CHEMBL3628132 1 6.22
CHEMBL3628131 1 6.19
CHEMBL481245 1 6.14
CHEMBL3628210 1 6.12
CHEMBL457076 BENZYL FERULATE 1 6.11
CHEMBL1095574 1 6.09
CHEMBL66879 COUMARIC ACID 1 5.17
CHEMBL145 CAFFEIC ACID 3.0 1 5.06
CHEMBL32749 FERULATE -1.0 1 5.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3628212 Ki = 310.0 nM 6.51
CHEMBL3628211 Ki = 370.0 nM 6.43
CHEMBL3628132 Ki = 600.0 nM 6.22
CHEMBL3628131 Ki = 640.0 nM 6.19
CHEMBL481245 Ki = 720.0 nM 6.14
CHEMBL3628210 Ki = 750.0 nM 6.12
CHEMBL457076 BENZYL FERULATE Ki = 780.0 nM 6.11
CHEMBL1095574 Ki = 810.0 nM 6.09
CHEMBL66879 COUMARIC ACID Ki = 6680.0 nM 5.17
CHEMBL145 CAFFEIC ACID Ki = 8710.0 nM 5.06
CHEMBL32749 FERULATE Ki = 9430.0 nM 5.03