Assay Detail
Binding
CHEMBL3631252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat liver microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate incubated for 20 mins by HPLC analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Estradiol 17-beta-dehydrogenase 2 (CHEMBL1914268) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.37 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3629586 | — | — | 1 | 7.42 |
| CHEMBL3629587 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3629586 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3629587 | — | IC50 | = | 49.0 | nM | 7.31 |